Former Newcastle United boss Sam Allardyce fears that his old side will be relegated unless Rafael Benitez and Mike Ashley resolve their disputeThe Magpies are winless and joint bottom of the Premier League table with just two points from eight games.Manager Benitez has grown increasingly frustrated with Newcastle owner Ashley’s lack of support in the transfer market.But Allardyce, who was fired by Ashley in January 2008, believes that Benitez must succeed regardless of the resources at Newcastle.“If you’re going to be successful, harmony at the top’s very important – communication and pulling in the right direction,” said Allardyce told PA Sport, via ITV.“Whether that’s happening with Rafa and Mike, I’m not privy to that information, but certainly, from my point of view as a manager, the relationship between the owners and you as a manager is critical.“(A club) can succeed but you have to put your differences to one side, both the owner and you, as the manager, and work together to get on with the job.Virgil van Dijk praises Roberto Firmino after Liverpool’s win Andrew Smyth – September 14, 2019 Virgil van Dijk hailed team-mate Roberto Firmino after coming off the bench to inspire Liverpool to a 3-1 comeback win against Newcastle United.“Whether you like each other or not doesn’t particularly matter; as long as you do the business and the best for the football club.“I was there for seven months and never really had a relationship with Mike – he wasn’t the type. He wanted other people to run the club and he wanted to come along and enjoy the ride. I don’t know whether that’s changed or not.“Because (in the transfer market Benitez is) limited, as we all find ourselves with whatever club we’re at, we try and use our tactics and the players we’ve got to the best of our ability.“The Newcastle fans give (Ashley) a lot of stick, but he is the owner of the football club and he has put his money in.“Whether that’s enough or not he decides how much money he wants to give the club and it’s up to you as the manager to try and spend that as wisely as you can.“Only time will tell if Rafa has. He certainly did last year; he finished very, very strongly. This year’s a difficult start but maybe again they’ll come through. New players again – we all have to settle players in very quickly, and that’s very demanding as a manager.”Newcastle will next face Brighton in the Premier League on October 20.
The English legendary footballer ended his international career with 120 caps with the Three Lions in the 3-0 win over the United StatesLegendary footballer Wayne Rooney is surely happy after he retired from international football with a 3-0 win over the United States in front of his fans at Wembley Stadium.“I’m happy with what I’ve contributed to the national team and I look forward now to the next few years and watching this team progress,” he was quoted by the BBC.“I know some ex-players I’ve spoken to can’t come to terms with England doing well.”“I wouldn’t say I regret never winning a trophy with England,” he commented.Crouch: Liverpool could beat Man United to Jadon Sancho Andrew Smyth – September 14, 2019 Peter Crouch wouldn’t be surprised to see Jadon Sancho end up at Liverpool one day instead of his long-term pursuers Manchester United.“I have given everything when playing for England and I’ve tried to make us successful. Sometimes everything just isn’t enough.”“I’ve had my time and it didn’t quite work out in terms of trophies,” he added.“They called the team I played in the ‘golden generation’ but this team has also got superstars like Harry Kane, Raheem Sterling, and John Stones.”“This is a great young squad with other players who can come in if there are injuries,” he concluded.
This is a developing story- Updates will be posted as they are made available. Facebook0TwitterEmailPrintFriendly分享A woman suffered life-threatening injuries after being struck by a semi-truck on the Seward Highway just outside of Girdwood at mile 93 Monday night. According to Girdwood Fire Department the crash occurred around 11:19 pm prompting the closure of the highway until 3:20 am, Tuesday.Anchorage Police Department said the driver stayed at the scene and cooperated with the investigation.
ADC AUTHOR The Navy, the Navy’s Southwest Region Command and the San Diego Association of Governments (SANDAG) have entered into new contract to explore development of a major public transit hub to be located at Naval Base Point Loma, The San Diego Union-Tribune reported Wednesday.The proposed transit station, locally nicknamed as “San Diego Central Station,” would need space allocated at the 70-acre base that overlooks Interstate 5 in Point Loma. It would serve as a future transportation hub that connects all rail types and provides access to San Diego International Airport, according to the report.“This is the beginning of what I expect to be a long partnership with the Navy,” said Steve Vaus, who chairs the SANDAG board and is the mayor of Poway. “The MOU creates the opportunity for SANDAG and the Navy to do something very special in the region, clearing a path for us to work on a major transportation hub and providing a transit link to the airport,” he added.Located close to downtown San Diego and its airport, the expansive property could feature millions of square feet of multi-purpose office space as well as multi-family housing towers and some retail.The Navy eventually plans to seek redevelopment proposals for the property in exchange for new facilities for the installation’s on-base missions, according to the report.“The Navy remains dedicated to creating a more modern, efficient workspace … while working closely with SANDAG and other entities to foster robust community engagement for this project,” said Capt. Mark Edelson, commanding officer of Naval Facilities Engineering Command Southwest.Navy photo by Mass Communication Specialist 2nd Class Derek Harkins
Comments Now playing: Watch this: TVs Video Games 1:55 The dazzling LG B8 55-inch OLED TV has never been priced this low. Sarah Tew/CNET Cheeps! If you happen to live in the vicinity of White Lake, MI, come on out to the White Lake Township Library tonight at 6:30 p.m. I’ll be there talking about some of my favorite money-saving tips and tricks (including something I’ve never discussed here). Everyone who shows up gets a cool prize, and some folks will win even cooler prizes in a raffle. Hope to see you there!You know me: I’m all about the cheap TVs. I prize low prices over picture quality, especially when the latter is “good enough.”But there’s a whole other category of people (including many of my esteemed CNET colleagues) who lean the other way: They want the best possible image quality, period. Price be damned.Thankfully, it doesn’t always have to be. Today only, and while supplies last, Newegg has the LG B8 55-inch OLED 4K TV for $1,098.88 — the lowest price to date and a savings of at least $400 over other stores. (Amazon and Best Buy are both currently at around $1,600.) Forget damned; more like “damn!”See it at NeweggOne important thing to note: This deal comes from Newegg proper. If the inventory runs out, that link will still work, but you’ll likely end up seeing a slightly different price from a third-party seller. Does that matter? It might. Newegg is an authorized LG dealer. If you buy from an unauthorized dealer, LG may not honor warranty claims.The B8 is, according to CNET’s resident expert, David Katzmaier, “the best high-end value TV.” In other words, even though it was still pretty pricey when he reviewed it, overall image quality was second only to LG’s even-pricier models.It features a super-slim design, four HDMI inputs, built-in Google Assistant and all the other advanced goodies you’d expect.The B8 is super popular with owners, too. It has a 4.6-star average at Amazon and a 4.7 at Best Buy. Now, will I still argue that most folks will be just as happy with, say, a 55-inch TCL Roku TV in the $400 range? Absolutely. But if you want the best, at least here you can get it for a lot less than just a few months ago.Your thoughts? Share your voice Walmart LG Titanfall 2 deal: Just $5!Game time! Titanfall 2 was released in late 2016 to mostly glowing reviews. Price then: $60, the same as pretty much every new videogame release.For a limited time, and while supplies last, Walmart has Titanfall 2 for Xbox One for $5. Yep: Five. Bucks. And that’s for a boxed copy, not a download.See it at WalmartFear not, PS4 owners: Walmart also has Titanfall 2 for PS4 for $7. Regular price on both editions: $20. (That’s also proof-positive that you should never buy a videogame when it’s first released.)See it at WalmartShipping isn’t free unless you hit at least $35 in your shopping cart. If you don’t have more to buy, choose in-store pickup to bypass the shipping charge.This is a seriously good game deal. Read GameSpot’s Titanfall 2 review to learn more.CNET’s Cheapskate scours the web for great deals on PCs, phones, gadgets and much more. Note that CNET may get a share of revenue from the sale of the products featured on this page. Questions about the Cheapskate blog? Find the answers on our FAQ page. Find more great buys on the CNET Deals page and follow the Cheapskate on Facebook and Twitter! Tags 7 Best laptops for college students: We’ve got an affordable laptop for every student. Best live TV streaming services: Ditch your cable company but keep the live channels and DVR. The Cheapskate LG B8 is the 2018 OLED TV to buy
As many as 17 percent of those polled said that they wouldn’t consider buying another truck, citing fuel economy and cost of maintenance as the primary factors for leaving the segment. Of those that have already dumped their trucks, 35 percent switched to a sedan and, surprisingly, only 37 percent moved to an SUV or crossover. This goes against the broader market trends we’re seeing, where SUVs are crushing sedan sales.What we’d be curious to see is how these types of sentiments found by CarGurus translate across different kinds of trucks. For example, does a midsize truck owner care more about their brand than a full-size truck owner? Or is the person who buys an F-150 more of a tech evangelist than the person who drives a Ram 3500 HD?We’ll have to wait until next year to find out. More From Roadshow 45 Photos Share your voice 21 Photos Car Culture Trucks Enlarge ImageTrucks have always been big business, but now buyers are more price-conscious and less brand loyal and that could change the whole game. Emme Hall/Roadshow Truck buyers are an interesting group of people. Among them, you’ll traditionally find some of the most brand-loyal consumers in the automotive space as well as some of the most price-conscious. The truck segment is also interesting because of how quickly it’s changing. What were once utilitarian penalty boxes on wheels are now rivaling some of the world’s most popular luxury cars when it comes to opulence. To help make sense of what’s going on in the world of trucks, CarGurus.com has again conducted a survey of truck owners. This time around, CarGurus expanded its sample size significantly to more than a thousand current and former truck owners. What were the takeaways?To start with, the upward march of truck prices is beginning to undermine some of that fierce brand tribalism that we’ve traditionally associated with truck buyers. CarGurus found that 67 percent of buyers think trucks are too expensive in 2019, with more than 80 percent of survey participants over the age of 45 agreeing with that. 68 Photos Go west, young trucker, in the 2019 Ram 1500 Post a comment Tags 2020 Hyundai Palisade review: Posh enough to make Genesis jealous 2020 Kia Telluride review: Kia’s new SUV has big style and bigger value 0 The 2020 Chevy Silverado HD gets a new look to match its capability Around 54 percent of those surveyed said that price would cause them to consider switching brands, with 70 percent saying that they’d jump ship to another brand if their current make boosted prices by $10,000. The second biggest cause for switching was fuel economy, which 47 percent of buyers said would make them change up.One of the factors driving prices of trucks up — apart from luxury touches like leather and wood — is the massive increase in the amount of tech that trucks have seen in recent years. Whether that is something as simple as a touchscreen infotainment system or as complex as Chevrolet’s super-advanced cylinder deactivation system, it all costs money. Still, a slim majority of 54 percent of buyers approve of how tech-laden their trucks are. “With pickup truck prices on the rise, many owners are reconsidering their current brand, or in some cases whether they will repurchase a pickup at all,” said Madison Gross, director of consumer insights at CarGurus, in a statement. “While truck owners still have strong brand and category loyalty, the challenge for car manufacturers and dealerships is that loyalty is increasingly less reliable as a driver of sales.” The 2020 Ford F-Series Super Duty gets a new look and more capability 2020 BMW M340i review: A dash of M makes everything better Ram Chevrolet Ford Nissan Toyota
Union Finance Minister Arun Jaitley will present the most challenging budget of the Narendra Modi era on Wednesday (February 1). This would be the first after the prime minister took the shocking financial step of demonetisation on November 8 last year.Also read: From halwa ceremony to leather briefcase, interesting traditions of Union Budget 2018Now, to what extent will the Budget 2017 be able to satisfy the common man after the November shock therapy is for time and the experts to tell. Meanwhile, we can focus on some lighter facts related to India’s budget, things that would make it a not-so-tedious read amid all the complicated calculations:A Scottish presented India’s first-ever Budget: The first-ever Indian budget was presented by James Wilson, the founder of The Economist, in April 1860. Wilson was the Finance Minister of the Indian Council which had advised the Indian Viceroy. He passed away a few months after presenting his Budget.The Indian to present first-ever Budget: The first-ever budget in independent India was presented by R K Shanmukham Chetty, the country’s first finance minister, in November 1947. That budget covered a period of seven-and-half months between August 15, 1947, and March 31, 1948. Chetty had also introduced the term ‘Interim Budget’ during his speech in 1948-49. It meant a budget for a short period.A scandal had broken in the UK over its budget the same year it was presented for the first time in independent India. The then British Chancellor of the Exchequer, Hugh Dalton, had met a journalist on the Budget Day after he walked into the British parliament and revealed to the latter a few details on tax changes that he had in his plans. The journalist broke the story before the speech was made and Dalton had to step down. It is said that the incident had made Chetty extra-cautious while preparing independent India’s first budget back home.John Mathai did not read out the Budget: John Mathai, the successor to Chetty and in office between1949-50 is said to have delivered the most plain budget speech ever. He had decided not to read out the budget and told the members that a White Paper including all details had been circulated. The highlights of this budget were setting up of the now-defunct planning commission and beginning of the five-year plans. Mathai also used the opportunity to give a speech on economic policy.Morarji Desai presented the Budget 10 times, the most: It is said the credit of turning Budget into a ‘tool of publicity for the finance minister’ goes to former prime minister Morarji Desai, who had presented it the maximum number of times: 10.Desai presented the Budget on his unique birthday twice: On two occasions, Desai had presented the Budget on his birthday – February 29. That happened in the years 1964 and 1968.The 1973 Budget was ‘Black’ one, while the 1997 one was called ‘Dream’: While the Budget of 1973-74 was called the ‘Black Budget’ owing to a deficit of Rs 550 crore, that presented by former finance minister P Chidambaram in 1997 was called the ‘Dream Budget’ owing to its roadmap for big reforms.Two presidents have presented Budget as FMs: Other than Pranab Mukherjee, R Venkataraman was the only finance minister who later went on to become the president of India.Yaswant Sinha presented four Budgets under difficult conditions: Yaswant Sinha, who presented five Budgets under two governments, had faced challenges almost every time he presented it as the NDA’s finance minister. While the 1999 Budget was presented after the Pokhran II blasts, the 2000 was presented after the Kargil war. Similarly, his presentation in 2001 came after the horrible earthquake in Gujarat. His budget presented as the finance minister of the National Front government in 1991 was also in the wake of the forex crisis.Only one woman presented Budget: The only woman to have presented the Budget is late prime minister Indira Gandhi, who did so in 1970-71 after Desai’s resignation.Railway and general budgets were separated in 1924: The railway budget was separated from the general budget in the year 1924. They have been merged this year.First disclosure scheme for black money in Budget: The first disclosure scheme for black money came in the Budget of 1965-66.Three PMs presented budgets: Three prime ministers – all from the family – Jawaharlal Nehru, Indira Gandhi and Rajiv Gandhi had presented the Budget while serving as prime minister.Biggest-ever Budget was presented in 1991: The biggest Budget ever in the history of India was that of 1991 when the country’s economic policy underwent a complete change. Former prime minister Manmohan Singh had presented that budget and late PV Narasimha Rao was the prime minister then.Budget timing was changed from 5 pm in 1999: Earlier, the Budget used to be presented at 5 pm, which was essentially a continuation of the colonial-era practice. It was during the NDA government of Atal Behari Vajpayee in 1999 when this ritual was changed. That year, the budget was presented by Yashwant Sinha at 11 am. PM Modi’s government also made another change by bringing the Budget ahead by a month to present it on February 1.The halwa ceremony: Printing of the Budget documents begin with the annual halwa (a sweet dish) ceremony. It marks the beginning of lockdown for many officials in the Ministry of Finance who remain in the budget printing press till the finance minister’s speech gets over. During this time, the officials are not even allowed to contact their family members.
Share Jose Luis Magana/APAssociate Attorney General Rachel Brand speaks during the opening of the summit on Efforts to Combat Human Trafficking on Feb. 2 at the Justice Department.The No. 3 official at the Justice Department will be stepping down after less than a year, leaving a key vacancy in the succession of people who are tasked with overseeing the investigation into Russian interference in the 2016 election.Sources familiar with the decision tell NPR that Associate Attorney General Rachel Brand is leaving her post. The source said Brand, who was sworn in last May, has been in talks about becoming the top lawyer at Walmart.For months, other sources said Brand has chafed at the limits of her post at DOJ. President Trump has repeatedly attacked the law enforcement agency and sought to cast doubt on special counsel Robert Mueller’s investigation into possible ties between Russia and the Trump campaign.Her role at the Justice Department was doubly important because Attorney General Jeff Sessions has recused himself from the Russia investigation, given his role with the Trump campaign. That left Deputy Attorney General Rod Rosenstein overseeing Mueller’s investigation, and Trump and GOP allies have attacked Rosenstein at times.Scrutiny of Rosenstein from conservatives allied with Trump escalated last week after a Republican memo authored by House intelligence committee Chairman Devin Nunes, R-Calif., detailed how Justice Department and FBI officials including Rosenstein authorized surveillance on Trump campaign foreign policy adviser Carter Page, who had contact with Russians.Asked last Friday after the memo’s release whether he still had confidence in Rosenstein, Trump responded, “You figure that one out,” raising the specter he might fire the deputy attorney general. However, the White House quickly denied any plans to remove Rosenstein. But if he was let go, that would have left Brand next in line to oversee Mueller’s investigation, among Rosenstein’s other responsibilities.Brand is an expert in national security and helped defend the administration’s efforts to renew a foreign surveillance law. But she had a relatively small staff and a portfolio of issues that focused mostly on civil litigation, civil rights and other issues. In recent months, Brand delivered speeches in the administration’s fight against human trafficking.Her office oversees the Antitrust Division, the Civil Division, the Environment and Natural Resources Division, the Tax Division, the Office of Justice Programs, the Community Oriented Policing Services, the Community Relations Service, the Office of Dispute Resolution, the Office of Violence Against Women, the Office of Information and Privacy, the Executive Office for United States Trustees and the Foreign Claims Settlement Commission.Brand was also a top Justice Department official in the George W. Bush administration, helping pick nominees for federal judgeships. And she previously clerked for Supreme Court Justice Anthony Kennedy.“Rachel Brand is a lawyer of the highest caliber and integrity. I was proud to work for her in the Bush administration when she ran the Justice Department’s Office of Legal Policy and was proud to call her a colleague at [George Mason University’s] Scalia Law School,” national security expert and adjunct law professor Jamil Jaffer told NPR. “I’m certain that she’ll do great things going forward and will be in public service again in the near future.”The news of Brand’s departure was first reported by the New York Times.Copyright 2018 NPR. To see more, visit http://www.npr.org/.
Usually, children with symptoms of attention deficit hyperactivity disorders (ADHD), a common behavioural disorder in kids, like poor concentration, hyperactivity and learning difficulties, tend to improve with age.However, the disorder does not improve in some kids and one reason may be the persistent parental criticism, reveals a new research.“Children with ADHD, whose families continued to express high levels of criticism over time, failed to experience the usual decline in symptoms with age and instead maintained persistent, high levels of ADHD symptoms,” said Erica Musser, assistant professor at Florida International University in US. Also Read – ‘Playing Jojo was emotionally exhausting’The researchers studied a sample of 388 children with ADHD and 127 without, as well as their families, over three years. Of the children with ADHD, 69 per cent were male, 79 per cent were white and 75 per cent came from two-parent households. They measured changes in ADHD symptoms over that period and measured the parents’ levels of criticism and emotional involvement.Parents were asked to talk about their relationship with their child uninterrupted and were then rated by experts for levels of criticism — harsh, negative statements about the child, rather than the child’s behaviour —and emotional over-involvement — overprotective feelings toward the child, the study, published in the Journal of Abnormal Psychology, showed. Only sustained parental criticism was associated with the continuance of ADHD symptoms in the children who had been diagnosed with ADHD, the study concluded.
Illambazar (Birbhum): Brushing aside Prime Minister Narendra Modi’s allegations that there is no democracy in Bengal, Chief Minister Mamata Banerjee said he is not speaking the truth and BJP is stifling the voice of democracy and creating trouble everywhere.Modi had alleged that democratic movements have been curbed in Bengal in an interview to a private television channel on January 1. She was addressing a gathering in connection with public distribution here on Thursday afternoon. “He is not speaking the truth. BJP is choking the voice of democracy and any one criticising them is being pulled up. BJP is creating trouble everywhere.” Also Read – Rain batters Kolkata, cripples normal lifeBanerjee said: “The people in Bengal are living peacefully and their democratic rights have not been curtailed. On the contrary, BJP is demolishing the institutions and creating trouble everywhere.” She said the people in Bengal have been practicing Hinduism since birth. “We have heard about the Vedas from our birth and from our early childhood learnt to respect the religion of others. The Hindus, Muslims, Christians and Sikhs have lived peacefully for several generations in Bengal. But now some people wielding lathis and wearing headbands are teaching us which religion we will have to follow. We believe in the philosophy of live and let live,” the Chief Minister added. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedLauding folk artistes, Banerjee said they are proud of Bengal. “Baul music has been appreciated by people in foreign countries and they are proud of Bengal,” she said, adding that there was a time when people did not respect the folk artistes and their financial condition turned from bad to worse. The state government is now giving a stipend of Rs 1,000 to 2 lakh folk artistes and all the departments have been instructed to invite them for programmes. “Joydeb Mela in Kenduli is attracting people from all over the world and more and more people are listening to Baul music now. Baul singers are natural artistes. Without any formal training they sing perfectly and their renditions touch our hearts,” she said. Banerjee said major development has taken place in Birbhum district in the past seven years. Vast areas surrounding Tarapith Temple have been given a new look and more bridges are coming up which will improve communication. She said despite loan repayment worth Rs 48,000 crore, the state government has prepared schemes for all sections of people. More than 8 crore people are being given rice at Rs 2 per kilogram and the state government is giving a huge subsidy for the project. Kanyashree has helped girls carry on with their studies up to the post-graduate level. “We have made plans for everyone and we are proud of our youths who are the future of our country,” Banerjee said.
Travelweek Group Posted by << Previous PostNext Post >> Thursday, April 6, 2017 Remembering Patrick Doherty, beloved industry veteran Share TORONTO — When referring to the dates on his tombstone, with the date of his birth on one end followed by a final date on the other, Patrick Joseph Doherty said what mattered most of all was “the dash between those years.”Wise words from the larger-than-life travel industry veteran who passed away peacefully, surrounded by family, on March 27 at The Villages Regional Hospital near Ocala, Florida.Known by friends and colleagues as the “Redman”, Doherty was born in 1940 in Dublin, Ireland where he eventually worked as a young man in local shipping yards. Guided by his entrepreneurial spirit, he immigrated to Canada in 1968 and co-founded Alltour Marketing Support Services Ltd., the distribution partner of the Canadian travel industry. In the last quarter of his illustrious career, he joined Baxter Publishing where he established a multitude of partnerships that lasted well into his retirement.In his obituary, Doherty’s family spoke of his love of life, golf, travel and piano bars, and said no one was too insignificant for him to reach out with a friendly smile and say, “My pleasure to meet you!” He loved people of all ethnic backgrounds, ages, professions and interests.More news: Help Princess Cruises break the world record for largest vow renewal at seaDoherty was a husband, father, grandfather, great-grandfather, mentor, friend and business partner. He is pre-deceased by his wife of 40 years, Catherine (Dolly), and is survived by his sister, Mary O’Sullivan, and brother, Harry Doherty in Dublin, daughters Elizabeth, Martina and Sarah, sons-in-law Peter and Tony, grandchildren Nicole, Patrick, Celene, Reilly, Aidan, Ryan, Caleb and Gabriel, and great-grandchild Connor.A visitation will be held on April 9 from 2:00-4:00 p.m. and 7:00-9:00 p.m. at Glendale Memorial Gardens, 1810 Albion Road, Etobicoke, Ont. Funeral mass will be held at 11:00 a.m. on April 10 at Saint Peter’s Church, 100 Bainbridge Avenue, Vaughan, Ont. Cremation has already taken place. Arrangements in care of Glendale Memorial Gardens (416) 697-1803.In lieu of flowers, donations can be made to the Heart and Stroke Foundation.
When Allison Ruddick was diagnosed with stage 3 colorectal cancer in October 2014, she turned to the world of hashtags.After her initial diagnosis it wasn’t clear if the cancer had metastasized, so she was in for a nerve-wracking wait, she says. She wanted outside advice. “But they don’t really give you a handbook, so you search kind of anywhere for answers,” Ruddick says. “Social media was one of the first places I went.”Under the hashtags #colorectalcancer and #nevertooyoung on Facebook, Twitter and Instagram, other patients were sharing a fuller picture of their experience with cancer treatments.Later she found even more advice on specialized message boards. Patients posted everything from the details of their surgeries to the ice packs they liked best as they recovered. “These weren’t things that my doctor could tell me, and as much as I appreciate their expertise, it’s also really limited by the fact that they’ve never really experienced any of this themselves,” Ruddick says.Partly because of that experience gap, doctors and drug companies are keen to learn from online communities, too. They’re analyzing social networks to get a faster, wider look into how patients react to drugs, sometimes picking up information about side effects that clinical trials missed.The rule of threeStanford University dermatologist Bernice Kwong specializes in skin conditions that tag along with cancer treatments. In her practice and on patient message boards, she’s constantly on the lookout for symptoms that could be drug reactions.In January 2017, a patient came to Kwong’s office with an unusual complaint. “I’ve noticed that when I work out, I just get really hot,” he told Kwong. “I don’t sweat anymore, and I used to sweat so much.” He was taking a drug called Tarceva, or erlotinib, that’s used against lung cancer.At first, Kwong thought the problem might be hormonal. But soon after, two more of her patients at Stanford on the same drug reported that they’d also stopped sweating. “Anytime something hits three, I think, OK, I gotta look into this a little bit more,” she says.But she hadn’t seen any reports before of a lack of sweating — hypohidrosis — as a side effect for Tarceva. Her sample size of three patients was small. She’d need more data to figure things out.From talking with patients and perusing online forums, Kwong knew people discussed their treatments and side effects online. In fact, hundreds of thousands of people participate in support groups and communities she’d looked at on the website Inspire. She partnered with the site with the idea that its trove of patient reports could connect more dots between hypohidrosis and Tarceva.A sharper data setInspire’s focused groups are filled with patients’ experiences with diseases and treatment, so analyzing posts requires less filtering than Facebook or Twitter data would, says Nigam Shah, a Stanford University bioinformatics specialist who collaborated with Kwong. It also helped that the skin reactions they were interested in are relatively easy for patients to describe.Still, the posts on Inspire’s boards are less precise than insurance claims and health records typically used for studies on side effects.Take loss of sweating. Most doctors would refer to that as hypohidrosis, so a records-based study could focus on that phrase. In online message boards there’s a lot of variety. One person’s “I can’t sweat anymore” might be another’s “I’m overheating.”Kwong, Shah and their colleagues used a deep learning algorithm to process the phrases surrounding reports of symptoms, basically finding contextual clues to identify the different ways patients referred to side effects.In 8 million posts on Inspire from a 10-year period, 4,909 users mentioned Tarceva, or erlotinib generically. Although clinical reports don’t link the drug and hypohidrosis, 23 patients wrote about the medicine and loss of sweating in the same post — a statistically significant connection, Kwong says. The research group’s findings were published in JAMA Oncology in March.Using the same approach to monitor posts about a different class of immunotherapy cancer drugs, the researchers found mentions of autoimmune blistering that also predated the clinical reports of the side effect.Given the stakes of cancer treatment, Kwong says she’s inclined to help patients manage side effects instead of stopping a given drug. But earlier alerts from systems like this could have made a difference in her practice. “If we had had this program already, I would’ve been looking out for [blistering] sooner and maybe I would’ve noticed it earlier in some patients,” Kwong says.How clinical trials miss side effectsFrom numbers alone, it’s no surprise that clinical trials for drugs don’t pick up every side effect. The Food and Drug Administration first approved Tarceva in 2004 on the basis of a trial that enrolled 731 patients, 488 of whom received the drug. Uncommon effects might not show up in a group that size.On Inspire’s message boards, more than 10 times as many patients reported using Tarceva, so it’s reasonable to imagine that online posts could include reports of rarer side effects.And while drug trials do collect data on side effects, their overriding goal is to find out whether or not a drug works, says Dr. Aaron Kesselheim, a professor of medicine at Harvard University. “After a drug is approved, it is absolutely essential to continue to observe, follow and study the drug rigorously as it’s used in a larger population to try to really get a handle on the safety of the drug,” he says.Collecting data about a drug from insurance claims and health records typically happens with quite a time lag. So mining the Internet and social media for casual patient reports is tempting, Kesselheim says, because of its potential scale and speed. But the approach also has drawbacks. “You just get this tidal wave of data, and it’s hard to know how to assess it in a rigorous and thoughtful fashion,” he says.That hasn’t stopped drug companies from wading in. Roche has sampled mentions of their products from Twitter, Tumblr, Facebook and blogs to learn more about drug safety. GlaxoSmithKline has tried it too, analyzing millions of mentions of drugs from Twitter and Facebook.Much of the work published so far has focused on drug reactions. But scraping public social media data isn’t just a matter of product safety. The company Synthesio touts its social data services for drugmakers as a way to answer customer questions, conduct market research and influence purchasing.Surfing responsiblyIn terms of extending studies to mine even bigger networks, like Twitter or Facebook, for potential side effects, Kesselheim points to issues of representation and privacy. As with any analysis, a deep learning model like the one Shah used on the Inspire message boards can only make conclusions about the information it sees.And it’s hard to guarantee that message boards and social media represent all patients. In 2012, researchers gave 231 breast cancer patients in rural Michigan and Wisconsin computers, Internet access and training to use an online cancer support group. The researchers found that white women were much more likely to log on and post in the group than black women. Younger women were also more likely to post information.While the long-standing approach to post-approval drug studies — using health records and claims data — may be slower, Kesselheim says, they’re more established. “There are methodologies and tools that you can use in claims data to try to make sure that you are making conclusions that can be generalizable across different races and ethnicity and genders and parts of America,” he says.There’s also the issue of privacy — patients’ health records are protected by the Health Insurance Portability and Accountability Act of 1996, whereas public data online aren’t, Kesselheim says.For Stanford researcher Shah, this wasn’t an issue. Inspire’s privacy statement tells patients their posts may be used for research if they’re not private, and Shah feels comfortable following common sense rules when using public data. “As in, if somebody did [something] with my data and I would be upset, don’t do that with someone else’s data,” he says.But the newness of social media makes Kesselheim wary. “There are big questions that remain about how patient privacy is upheld in those social media contexts, and I think that’s a really big issue to think about moving forward as people are trying to use those outlets to provide insight into drug safety and side effects.”As a patient, Ruddick isn’t bothered by the idea of researchers and pharmaceutical companies studying data from social media and patient message boards, as long as the data are public or there’s mention of data sharing in a privacy statement.She works as a communications director in New York City, so she’s thought a lot about the nature of information online. “If I’m putting something out there on the Internet, it’s for the Internet. I know the world is going to see it,” Ruddick says.She knows other patients might feel differently, but she’s optimistic that analyzing patients’ interactions online could improve the treatments available. “It’s one thing, being in a lab and developing these drugs,” she says. “But it’s a completely different thing to see how they’re being used out there in the world, and to see how they’re affecting somebody’s life.” Copyright 2018 NPR. To see more, visit http://www.npr.org/.
A disabled artist-activist’s project to “make visible the human cost of austerity” in the run-up to tomorrow’s general election has visited the prime minister’s constituency, home to one of the most high-profile victims of his government’s austerity programme.Liz Crow’s We Are Figures project has seen her sculpt 650 figures out of river mud, one for every UK constituency and each linked to an individual story about a victim of austerity.And on Saturday (2 May), We Are Figures was in Witney, a constituency that is not only represented by the prime minister, but was also home to Mark Wood.Wood starved to death four months after he was found fit for work, and subsequently had his out-of-work disability benefits and housing benefit removed. Among those visiting the travelling exhibition of clay figures were members of the local Green party, of which Wood had been a member.At one point, there were UKIP, Green and Labour supporters in the We Are Figures van discussing the austerity stories at the same time.Lizzy Maries, a tour guide on the We Are Figures tour, said: “There was a lot of empathy. These were real stories that have happened to real people and that resonated with a lot of people.”She said that all of the visitors to the van in Witney – including Conservative party members – were “really respectful” to the project.She said: “So far, nobody has wanted to argue with us and say, ‘It’s not true, it’s all lies,’ although a lot of people do say, ‘We need austerity.’”Maries said she believed the exhibition would make some people think again about who they vote for.But she said that We Are Figures was not just about the election. “It’s also about keeping an eye on the people around you. It’s about the society we live in. It is about us as people creating a society that supports one another.“I definitely think that for a few people it will make them think. I also hope it will make them think past the election.”Pictured: The We Are Figures van outside David Cameron’s constituency office in Witney
Add to Queue Cynthia Salarizadeh 4 min read Get 1 Year of Green Entrepreneur for $19.99 The responsible professionals building the cannabis industry are not dodging the social issues inherent with the normalization of marijuana. The cannabis industry has been described as the “Wild West” but the fact is cannabis, and the products supporting its use, create opportunities for mainstream businesses in Canada and the US. Altria and Constellation Brands are two examples of the big brands jumping into cannabis with billions of dollars to spend on bringing new vaping, edible and paraphernalia products to market.While most of the news and discussion about cannabis focuses on consumables, the responsible professionals building the cannabis industry are anticipating social issues that arise with normalization and proactively developing solutions.Related: NFL Considers Options for Medical Use of MarijuanaSmoke gets in my eyes.Cannabis vaping and use of e-cigarettes are increasing and people who vape (and smoke) are getting push back from people who don’t. It ranges from being sent outside to enjoy their vape to dirty looks on the street when they exhale. At the same time, adults are allowed to choose for themselves whether to vape e-cigarettes or cannabis starting at ages 18 and 21, respectively.One company believes vaping does not have to impact the environment or other people. PHILTER™Labs, Inc is giving responsible adults the choice to vape in a traditional manner and to filter emission clouds based on a particular environment. Philter recently debuted the world’s first 4” x ½” dual-function filter developed by medical device experts with more than 20 years of experience. Philter’s first-of-a-kind technology lets responsible adults partake in universally acceptable vaping behavior.Personal rights and personal choice to vape or not to vape are essential in a polite society.Related: Harvest Buys Verano to Solidify Market Position Post-Prohibition (Whenever That Happens)Mother Nature thanks you.As a fast-growing channel for both the cannabis and nicotine markets, the vape market creates mountains of waste. From the consumer-focused packaging, to the vaporizer battery and pods, the amount of refuse generated is profound. Cannabis activist Katie Stone, says “Responsible recycling is necessary in the cannabis industry and, frankly it’s the right thing to do.”What works in other industries can be used as a blueprints for similar cannabis recycling programs. TerraCycle, known for recycling the unrecyclable, is geared to putting an end to the waste, one cartridge, vape pen, childproof bag at a time. Unfortunately, it is illegal to re-use the cannabis-holding portions of vape pens, however the materials that make up a vape pen — from plastics to electronics and batteries — can be recycled.Related: We Need to Clear the Smoke About Cannabis in the WorkplaceSexist advertising doesn’t cut it.As this newly legal industry develops, please don’t think that it will accept girls in thongs and half shirts in our advertising (as the beer industry did in the 90s ), or women in skin tight dresses at our trade shows (as auto shows still do) or women objectified in any other form.Organizations are being created daily to promote women in this industry. Kyra Reed, leader of Women Entrepreneurs in Cannabis, started a movement three years ago with the sole purpose to support women in this industry. The momentum of her #BetterTogether movement hasn’t slowed down.Related: We Have a Problem: The Cannabis Industry Is Losing Women LeadersLearning from the past.The cannabis industry has been compared to the wine/beer industry, but we’re smart enough today to learn from the past and make the future better. Cannabis and ancillary businesses are not just looking for opportunities to provide what the Wild West provided-gold and the pick and shovel, they are looking to the future to solve what happens after the entire industry regulates. Social Entrepreneurship Founder and CEO –shares Cannabis Professionals Are Tackling the Industry’s Big Issues Opinions expressed by Entrepreneur contributors are their own. April 26, 2019 Next Article Subscribe Now Guest Writer Green Entrepreneur provides how-to guides, ideas and expert insights for entrepreneurs looking to start and grow a cannabis business. Image credit: The Cannabiz Agency | Getty Images
View of a beach from a condo building in Florida, where bitcoin fever has hit the real estate market © 2018 AFP As of the end of last year, the digital currency was listed as a way to pay for some 75 properties for sale, especially in south Florida and California, according to the real estate firm Redfin.”Bitcoin accepted” is a message now seen in the description of homes for sale in the Miami area.One seller is going even farther, saying he will take only bitcoin (33 of them to be exact) for his half-million-dollar downtown condo in the Florida metropolis.Bitcoin has been on a roller coaster ride of late, shooting up to nearly $20,000 a piece in mid-December and then dropping sharply around Christmas. It started the year at around $14,000.Its use in real estate transactions is novel, and agents are wary because of its high volatility.”I’d be blown away if a year from now we see hundreds of real estate transactions in bitcoins,” said Jay Parker, Florida CEO for the Douglas Elliman brokerage agency.Still, such transactions can be useful for foreigners who want to invest in the United States and cannot otherwise do so, said economist and bitcoin expert Charles Evans of Barry University. “This seems to be driven by international investors who are circumventing inefficient banking and currency controls at home, and by US cryptocurrency enthusiasts,” Evans told AFP.”The governments in those countries restrict the amount of money that their residents are allowed to transfer abroad through the banking system. Bitcoin enables individuals there to bypass such restrictions,” he added.This could be a draw for investors, who even before the bitcoin rage were already hot on the real estate market in south Florida.Nearly half of all foreign buyers of property in south Florida are from Latin America.According to the National Association of Realtors, over the past five years, investors from Venezuela, Brazil and Argentina—in that order—have led purchases in this part of the state.Money laundering?Bitcoin offers another advantage for some foreign investors: it lets them dodge US economic sanctions.Evans cited the example of Venezuela, which imposes strict currency controls and is enduring runaway inflation that surpassed 2,600 percent in 2017.What is more, many senior officials in the government of Venezuela’s President Nicolas Maduro have been hit by sanctions imposed by Washington, which considers his administration a dictatorship.Evans said there is also a lot of interest in bitcoin among Iranians, whom he described as “doubly hit” with restrictions in Iran and international sanctions.It is an open secret that money laundering fuels the real estate market in south Florida. But instead of hiding the practice, bitcoin could have the opposite effect.The crypto currency “is a terrible medium for large-scale money laundering, because all bitcoin transactions are recorded in the publicly available transaction record known at the Blockchain,” said Evans.Although bitcoin has been associated with the drug trade and cyber attacks, Blockchain “leaves a lot of fingerprints,” former Florida representative Jose Felix Diaz told Politico.”So if you’re using it for illegitimate reasons, the state and the federal government should have every tool at their disposal to go after you,” Diaz said.Last year, Diaz sponsored a bill-turned-law that includes bitcoin in Florida’s laws for fighting money laundering.Real estate agent Parker also said money laundering via bitcoin is far from posing a risk because “the beneficial owners of the real estate are always going to be able to be traced.”Parker said the fad of doing real estate deals in bitcoin could be as volatile as the currency itself.”I think it’s a gimmick. There’s not much risk. The only risk is if the currency crashes before you can liquidate it,” said Parker.”I think the people that are using bitcoins to try to market their properties are doing it with the very purpose of getting you to write about it, getting their properties exposure,” said Parker. Citation: Bitcoin fever hits US real estate market (2018, January 14) retrieved 18 July 2019 from https://phys.org/news/2018-01-bitcoin-fever-real-estate.html Explore further Bitcoin fever has hit the US real estate market, especially that of Florida, offering foreign investors a way to dodge currency controls at home and US economic sanctions. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Bitcoin and cryptocurrency for n00bs
SHARE SHARE EMAIL environmental issues COMMENT crime against women crime, law and justice SHARE The CPI(M) MLA was making disparaging comments against the officer for her attempt to stop an allegedly illegal construction in ecologically sensitive Munnar The Kerala Women’s Commission on Monday registered a case against CPI(M) legislator S Rajendran for his remarks against Devikulam Sub-Collector Renu Raj.The Devikulam lawmaker had made the remark on February 8 after the young IAS officer tried to stop the unauthorised construction of a shopping complex in the tourist town of Munnar in Idukki district.Commission sources said the case was registered on the basis of media reports about the MLA’s purported remarks against the official.Television channels had aired visuals showing the legislator making the disparaging comments that the sub-collector lacked brains, had no powers to intervene in the construction as building rules comes under the panchayat.“She doesn’t have brains. She studied only to become a collector. Such people will have only so much brains. Should she not study the sketch, plans. A collector cannot intervene in a panchayat construction,” the MLA had reportedly said on Friday after revenue officials tried to stop the construction.Illegal constructionRaj, who was appointed as the Devikulam sub-collector in November last year, on Sunday said a memo had been issued to the panchayat on February 6 to stop the illegal construction.But the work was still going on.The Kerala High Court had in a 2010 judgement said for any new construction in Munnar, a no-objection certificate had to be obtained.No NoC was obtained when the construction work of the four-storeyed shopping complex was taken up, she said. Kerala February 11, 2019 civil and public service Published on COMMENTS
June 25, 2019 Telangana SHARE SHARE EMAIL SHARE The Errum Manzil in Hyderabad – Nagara Gopal Published on Telangana CM wants to build a complex where 150-year-old Errum Manzil stands COMMENT Will Hyderabad lose the 150-year-old heritage structure Errum Manzil to a modern Legislative Assembly complex? This question is uppermost among the people of this 428-year-old city ever since Telangana Chief Minister K Chandrasekhar Rao made the dramatic statement last week that his government would spend ₹100 crore to construct a brand new structure to house the Legislature complex and identified the 17-acre land and the iconic building built atop a hillock. Heritage lovers, activists, residents of the neighbourhood, and the legal heirs association of Nawab Fakhrul Mulk Bahadur, who built the Errum Manzil in 1870, have written to the Chief Minister, urging him to save the palace complex with 150 rooms. As action started picking up with visits of officials and with the date for foundation stone laying set for June 27, a PIL too was filed in the Telangana High Court on Monday.The controversy Known for his penchant to propose grandiose building plans, KCR has invariably landed in controversy colliding with heritage structures every time. Ever since the formation of Telangana in 2014, he has been toying with plans to build a completely new Secretariat and Assembly complex.He first set his sights on the 65-acre Government Chest Hospital in Erragadda, a over 100-year-old Nizam era building called the Irranuma Palace. With opposition from activists, the move was shelved. Then, his attention turned to Bison Polo grounds in Secunderabad. This, again, raised a hue and cry.But KCR did not give up. Overcoming the initial cold response, he met Prime Minister Narendra Modi as also Home and Defence Ministers and got their nod. The grounds are part of the Cantonment area and house the Gymkhana stadium. Also, part of the complex is the Parade Grounds, the lung space of Secunderabad, where the Independence Day function takes place. The popular explanation for the move to shift the Secretariat complex is KCR’s belief in astrology and Vaastu. Apparently, the existing complex was ‘‘unfavourable” for him for an election in 2019, and he even avoided shunned going there for a couple of years. However, after the bold decision to prepone elections to December 2018 and the landslide victory that KCR scored, things seemed to have changed. KCR moves fastWith a friendly Chief Minister in neighbouring Andhra Pradesh, YS Jaganmohan Reddy, KCR moved swiftly. He acquired portions of the Secretariat belonging to AP and quickly decided to rebuild the entire complex, and then hit upon the idea of siting the Assembly in Errum Manzil. The cost of this grand plan is ₹500 crore.While residents of Secunderabad are heaving a sigh of relief that they will not lose the green space or have to face traffic hassles, people of Punjagutta, which is on the busy Khairatabad-Ameerpet stretch in the heart of Hyderabad, will have to face up to these issues.The existing Legislature building, housing both the Assembly and Council, is part of the Public Gardens. The impressive structure was built in 1905 to mark the 40th birthday of the 6th Nizam, Mir Mahabub Ali Khan. The legal heirs association, in a letter to the Chief Minister, requested him to drop the proposal, saying that an important milestone in the history of Hyderabad would go if Errum Manzil palace was demolished. The architecture, in European style, gave it a special position among the many structures. It also housed 150 rooms, a polo ground, a pond for boating and a private forest.According to accounts of Nizam’s history, Fakhr-ul-Mulk was a minister with the 6th Nizam and had constructed beautiful palaces. The famous Nizam College, Chest Hospital, etc., were built by him and his descendants and handed over to the State when Hyderabad merged with the Indian Union in 1948. Successive State governments have used the buildings as offices of the Engineer in chief, Public Works Department, Jala Soudha, etc. “The heirs also pointed out that the palace had served as the Public Works Department office for decades and had become a known landmark in the city,”, in the statement by Nawab Shafath Ali Khan, the Secretary. COMMENTS
Soch badlo papa: BJP MLA’s daughter who married Dalit boy makes emotional appeal to dad on live TVSakshi, the MLA’s daughter had earlier filed a petition in the Allahabad High Court, seeking protection to “live a peaceful life” as a married couple. She spoke to her dad from the Aaj Tak studio on Friday.advertisement India Today Web Desk New DelhiJuly 12, 2019UPDATED: July 12, 2019 19:12 IST Sakshi Misra, daughter of MLA Rajesh Misra had uploaded a video on social media and informed about her wedding to Ajitesh Kumar.HIGHLIGHTSBJP MLA Rajesh Mishra’s daughter Sakshi on Friday made an emotional appeal to her fatherEarlier, Sakshi had said she was being threatened by her father and “his men” because she had married a Dalit manOn Friday, Sakshi asked her father to change his thinking and requested him not to discriminateSakshi, the daughter of BJP MLA Rajesh Mishra, whose viral video gripped the country this week, on Friday made an emotional appeal to her father with whom she spoke while sitting in the studios of Aaj Tak TV.Sakshi, in her viral video, had said she was being threatened by her father and “his men” because she had married a Dalit man. On Friday, Sakshi appeared on Aaj Tak TV and while in the studio, spoke to her dad over a call.”I had so many dreams and wanted to study. I used to tell my father to take me to work but he never took me seriously,” Sakshi said in a trembling voice. In an emotional message, Sakshi asked her father to change his thinking and requested him not to discriminate.Sakshi claimed that her father never let her step out of the house. “He [Sakshi’s father] had no clue what was happening with us. My brother and mother used to harass me when you were in the office,” Sakshi added.When called, BJP MLA Rajesh Mishra alleged that his family was being harassed. As Sakshi spoke with her father on Aaj Tak, she broke down and apologised to him. Rajesh Mishra said he wished she finds happiness in life, but disconnected the call soon after.THE CASESakshi and her husband Ajitesh had earlier filed a petition in the Allahabad High Court, seeking protection to “live a peaceful life” as a married couple.The next hearing in the case has been fixed for July 15 as Sakshi Mishra and her husband Ajitesh were not present in the court.Sakshi Misra (23) had uploaded a video on a social media platform last week, making her marriage with Ajitesh Kumar (29) public.In another video, she alleged there was a threat to her life from her father, brother and an associate.The couple asked for security, contending that there was a threat to their life from the BJP MLA, who was “unhappy” with their marriage as Sakshi was a Brahmin and Ajitesh a Dalit.The petitioners prayed that police or Rajesh Mishra do not disturb them in “their peaceful living as both petitioners were major and had entered into marriage with a free will”.READ | Respect her decision: BJP MLA denies threatening his daughter for marrying DalitREAD | Tell your goons to back off: BJP MLA’s daughter fears for life after marrying Dalit, releases videoWATCH | BJP MLA’s daughter who married Dalit boy makes emotional appeal to dad on live TVFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySumeda Next
with very bright people,Bliss said he strives to keep up dialogue with his constituents She and Bisi Akande got married 51 years ago and are blessed with several children.
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